Taxol metabolism in rat hepatocytes
WebDec 31, 1994 · The antitumor drug taxol was metabolized to two major metabolites (RM1 and RM2) in adult male and female rat liver microsomes. The male rats produced RM1 2.6 … WebHoneybees products comprise of numerous substances, included propolis, bee pollen, and royal mud, which have longish been known for them medicinal and health-promoting properties. Their wide biological effects have been known also used since antiquity. Bee products are considerable to be adenine potential source of natural antioxidants such as …
Taxol metabolism in rat hepatocytes
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WebBSEP mainly transports monovalent conjugated bile acids and is a high-affinity taurocholate transporter. It is also responsible for the high-affinity transport of glycochenodeoxycholate, glycocholate and taurochenodeoxycholate, which are the major bile salt species present in human bile (Table 5.3) (Hofmann, 2007).The substrate specificities are in line with a near … WebSYD-1 (25 and 50 μM) did not affect the viability of hepatocytes in suspension after 1–40 min of incubation. However, the viability of the cultured hepatocytes was decreased by ∼66% as a consequence of treatment with SYD-1 (50 μM) for 18 h. Under the same conditions, SYD-1 promoted an increase in the release of LDH by ∼19%.
Web1. The uptake and metabolism of pentacaine, a novel carbanilate local anaesthetic agent, were studied using different rat-liver preparations.2. Pentacaine, added to a rat-liver microsomal suspension, elicited a type-1 spectrum with Ks of 2.3 μM. The Km for total metabolism of pentacaine by rat-liver microsomes was 33.5 μM and in isolated …
WebDec 20, 2024 · Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea … WebTaxol is a natural product, isolated from Taxus brevifolia, with increasing clinical applications because of its potent antitumor activity. Although it is mainly metabolized in …
WebThe present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
WebIn the present investigation, poly (propylene imine) dendrimers up to fifth generation (PPI G5.0) were synthesized using ethylene diamine and acrylonitrile. Lipoproteins (high … pension not credited in accountWebAug 1, 1994 · Abstract. Incubation of taxol with human hepatic microsomal fractions or freshly isolated human liver slices yields three metabolite high performance liquid … todays rbi usd rateWebFeb 8, 2024 · The rat is a widely-used model for human biology, but we must be aware of metabolic differences. Here, the authors reconstruct the genome-scale metabolic network … pension norderney mit hundWebJan 1, 1997 · In this study, the response of isolated rat hepatocytes to taxol was evaluated by correlating the changes observed in global indexes such as viability and heat … pension not credited in account sbiWebJan 1, 2016 · Taxol (paclitaxel) is a powerful anti-cancer drug widely used against several types of malignant tumors. Because Taxol may exert several side effects, a variety of … todays refinance mortgage rates in californiaWebThe biliary excretion of Taxol has been studied in rats and in a human patient receiving Taxol in a phase I trial, and the chemical structures of four of the rat metabolites and … todays refinance rates in nmWebHepatic mitochondrial functions related to fatty acid metabolism, including the respiratory control ratio, fatty acid oxidative capacity and carnitine palmitoyltransferase I activity, … todays rbob gas price