WebApr 12, 2024 · Data suggest that interactions between Sos1 (Son of Sevenless homolog 1) and Crk (proto-oncogene proteins c-crk) involve electrostatic interactions at binding sites. … WebSon of sevenless homolog 1 (SOS1), a member of the SOS family, is a cohesion protein that plays an important role in the intracellular signal transduction pathways [Citation 15]. …
Design of Orally-bioavailable Tetra-cyclic phthalazine SOS1 …
WebFeb 10, 2024 · Figure 10 shows that EGCG downregulated proinflammatory PI3K-AKT genes, which are as follows: Son of sevenless homolog 1 (Drosophila) (SOS1), Raf proto-oncogene serine/threonine-protein kinase aka proto-oncogene c-RAF (RAF1), Beta-Glucuronidase (GUSB), Insulin-Like Growth Factor I receptor (IGF1R), Cyclin-dependent kinase inhibitor … WebKRAS mutations (G12C, G12D, etc.) are implicated in the oncogenesis and progression of many deadliest cancers. Son of sevenless homolog 1 (SOS1) is a crucial regulator of KRAS to modulate KRAS from inactive to active states. We previously discovered tetra-cyclic quinazolines as an improved scaffold for inhibiting SOS1-KRAS interaction. portable heater tractor supply
Pharos : Target Details - SOS1 - National Institutes of Health
WebSon of sevenless homolog 1 (SOS1) is a crucial regulator of KRAS to modulate KRAS from inactive to active states. We previously discovered tetra-cyclic quinazolines as an improved scaffold for inhibiting SOS1-KRAS interaction. In this work, we report the design of tetra-cyclic phthalazine derivatives for selectively inhibiting SOS1 against EGFR. WebDatabases HGMD ClinVar FERMT1 20p12 .3 Fermitin family homolog 1 FERMT1 database FERMT1 FERMT1 Data are compiled ... is well conserved throughout evolution ... RIT1 RIT1 SOS1 2p22 .1 Son of sevenless homolog 1 SOS1 database SOS1 SOS1 Data are compiled ... domains. Normal gene product . SOS1 (son of sevenless homolog 1 ... WebSon of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins … portable heater trips breaker