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Titin /ˈtaɪtɪn/ (contraction for Titan protein) (also called connectin) is a protein that in humans is encoded by the TTN gene. Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring that is responsible for the passive elasticity of muscle. It comprises 244 individually folded protein … See more In 1954, Reiji Natori proposed the existence of an elastic structure in muscle fiber to account for the return to the resting state when muscles are stretched and then released. In 1977, Koscak Maruyama and coworkers … See more Titin is the largest known protein; its human variant consists of 34,350 amino acids, with the molecular weight of the mature "canonical" isoform of the protein being … See more Titin is a large abundant protein of striated muscle. Titin's primary functions are to stabilize the thick filament, center it between the thin filaments, prevent overstretching of … See more Titin has been shown to interact with: • ANK1, • ANKRD1, • ANKRD23 • CAPN3, See more The human gene encoding for titin is located on the long arm of chromosome 2 and contains 363 exons, which together code for 38,138 amino acid residues (4200 kDa). Within the gene are found a large number of PEVK (proline-glutamate-valine-lysine … See more The titin domains have evolved from a common ancestor through many gene duplication events. Domain duplication was facilitated by … See more Mutations anywhere within the unusually long sequence of this gene can cause premature stop codons or other defects. Titin mutations are … See more WebTitin is the largest protein known, it has 244 parts connected by unstructured peptide sequences. There is a simpler name for the chemical, and that name is Titin. There is no other way to list all 244 protein domains in a manner lower than 244. WebThe word is 189,819 letters long. It's actually the name of a giant protein called Titin. Methionyltreonylthreonylglutaminylalrylglycylphe office supply reading pa